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E-post: olav.spigset@legemidler.no
Olav Spigset er spesialist i klinisk farmakologi, overlege ved Avdeling for klinisk farmakologi, St. Olavs hospital og professor ved NTNU.
Articles by Olav Spigset
Topical tranexamic acid for prophylaxis of bleeding
- Kjersti Ausen,
- Hilde Pleym,
- Olav Spigset
06.01.2023:
Uncertainty surrounding possible thromboembolic events may prevent widespread use of tranexamic acid in surgery. Topical application may be an alternative. Tranexamic acid is an antifibrinolytic drug used routinely by intravenous administration in cardiac surgery and orthopaedics, but uncertainty...
Should pregnant women receive lower or higher medication doses?
- Andreas Austgulen Westin,
- Arne Reimers,
- Olav Spigset
30.10.2018:
Choosing appropriate medication doses for pregnant women is a difficult balancing act, as the mother's need for treatment must be weighed against the risk of fetal harm. The latter is frequently considered to be the most pressing concern, with the result that drugs are discontinued or doses reduced...
Therapeutic drug monitoring (TDM) repertoire in Norway
- Andreas Austgulen Westin,
- Ruth-Anne Larsen,
- Ketil Arne Espnes,
- Olav Spigset
12.11.2012:
Therapeutic drug monitoring (TDM) can be useful in a number of clinical situations (1). Measuring drug levels in blood, serum or plasma (a definition of these test materials is provided in Box 1) can reveal whether the patient has an aberrant drug metabolism or is non-compliant, or provide an...
Drug use and breastfeeding
- Hedvig Nordeng,
- Gro C. Havnen,
- Olav Spigset
15.05.2012:
During pharmaceutical treatment in the post-partum period there will often be a need to assess what drug would be the safest alternative if the woman is breastfeeding. Lack of knowledge among health personnel may result in breastfeeding women who are undergoing pharmacotherapy being instructed to...
An elderly man with atrial fibrillation and exacerbated diabetes
- Ketil Arne Espnes,
- Rikke Holm Løvaas,
- Olav Spigset
15.05.2012:
A man in his late seventies who had had well-regulated diabetes mellitus type 2 for the previous seven years suddenly developed a sharp increase in blood glucose and haemoglobin A 1c (HbA 1c) levels. A probable cause was at length discovered. After action had been taken, the values rapidly fell back...